LIFE PERSUADED addressed the problem of human exposure to plasticizers, as environmental contaminants, and their effects on health focusing on the children population through the following approach:
– Biomonitoring study to evaluate the exposure to di-2-ethylhexyl phthalate (DEHP) and Bisphenol A (BPA) in Italian children aged 4 to 14 years and their mothers through the biomonitoring study, in order to define exposure differences in relation to the area of residence, age and sex of children
– Case-control studies to evaluate the relationship between DEHP and BPA exposure and childhood pathologies (precocious puberty, telarca and obesity) by correlating the levels of chemicals measured in urine samples with the biomarkers of effect (hormones, BMI, etc.) related to the pathologies, as proxy of potential adverse effects
– Experimental study to study the effects and mechanisms of DEHP and BPA through the use of an animal model in a juvenile phase to which DEHP/BPA were administered at levels found in the children population.