Phthalates and bisphenol A biomonitoring in Italian mother-child pairs: link between exposure and juvenile diseases

Phthalates (diethylhexyl phthalate [DEHP] in particular) and Bisphenol A (BPA), extensively used as plasticizers, are non-persistent environmental contaminants whose well documented presence in humans raises concern since they act as endocrine disruptors (EDs), thus potentially affecting human health. EDs exposure during childhood deserves special attention since this represents a crucial susceptible phase of development.
Recent studies have associated the exposure to DEHP and BPA to endocrine related multifactorial diseases in children, in particular precocious puberty and obesity.
BPA acts as weak agonist of estrogen receptor a, interferes with thyroid homeostasis and with the PPARg (peroxisome proliferator-activated receptor gamma); phthalates are antiandrogens and interfere with PPARa.


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